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Dr. Beth Bailey

Research Interests

EDUCATION    

Temple University School of Medicine  
Ph.D., Physiology, May 1992
                         Philadelphia, PA                              

Pennsylvania State University
B.S., Biology, May 1986
                                         University Park, PA                                            


PROFESSIONAL  EXPERIENCE 

                    1997-2003

Assistant Professor, Department of Biology,
Ursinus College, Collegeville, PA
                                          1995-1997

Assistant Professor, Department of Biology,
Neumann College, Aston, PA


COURSES TAUGHT

                                                   BIO 306                  Human Physiology
                                                   BIO 306L                  Human Physiology Lab
                                                   BIO 349                  Experimental Physiology
                                                   BIO 349L                  Experimental Physiology Lab
                                                   BIO 212                  Cell Biology
                                                   LS 200                  CIE II

        

PROFESSIONAL SOCIETIES

International Society for Heart Research
Council on Undergraduate Research
American Heart Association, Basic Cardiovascular Science Council
American Physiological Society


AWARDS & FUNDING

National Institutes of Health AREA Grant – R15HL67797, 2001-2004,
Gender-Based Differences in Cardiac Calcium Regulation, Principal Investigator

Biological Sciences Research Fund Grant, Ursinus College, 1998-2001

Van Sant Award, Ursinus College, 1997, 1998, 1999, 2000, 2001

Grants 1000 Award, Ursinus College, 2000

SELECTED PUBLICATIONS & PRESENTATIONS
#indicates peer review publications
*indicates student author

#*Crary, M., *J. Dillon, *J. Slakoper, *J. Nolan, B.A. Bailey.  Sex-based differences in murine cardiac myocyte calcium homeostasis.  In preparation.

#Petre, RE, MP Quaile, EI Rossman, SJ Ratcliffe, BA Bailey, SR Houser, KB Margulies.  Sex-Based differences in myocardial contractile reserve.  In Press (American Journal of Physiology). 

#Petre, R.E., M.P. Quaile, S.J. Ratcliffe, E.I. Rossman, B.A. Bailey, S.R. Houser, K.B. Margulies.  Sex-based differences in myocardial calcium regulation.  Circulation 114(II), 2006.

#*Crary, M., *J. Dillon, *J. Nolan, BA Bailey.  Myofilament Calcium Sensitivity is Greater in Male than in Female Ventricular Myocytes.  Circulation 114 (II), 2006.

*Crary, Monica and Beth A. Bailey.  Sex-based differences in the contractile properties of freshly isolated murine cardiac myocytes.  The Pharmacologist 48 (1): 29, 2006.

*Dillon, John and Beth A. Bailey.  Are there differences in intracellular calcium handling between male and female murine cardiac myocytes? The Pharmacologist 48 (1): 30, 2006.

*Segalov., M., *S. Patel, B. Bailey.  Are There Sex-based Differences in Whole-heart Response to Sympathetic Nervous System Agonists? The Pharmacologist 46 (4): 131, 2004.

*Slakoper, J. and B. Bailey.  Are There Sex-based Differences in Cardiac Muscle Cell Response to Adrenergic Stimulation? The Pharmacologist 46 (4): 131, 2004.

Petre, R.E., E.I. Rossman, M. Bradley, J. Gaughan, K.B. Margulies, S.R. Houser, B.A. Bailey.  Sex-Based Differences in Contractility Reserve in Normal Feline Ventricular Muscle.  Biophysical Journal 94: Pg. 89a, 2003.

*Share, L., *Daniels, W., Bailey, BA.  Differences in Calcium Regulation between male and female murine hearts.  FASEB J. 16 (4): A35, 2002.

#Yang, Y., X. Chen, K. Margulies, V. Jeevanandam, P. Pollack, B.A. Bailey, S.R. Houser. 
L-type Ca2+ channela1C subunit isoform switching in failing human ventricular myocardium. 
J. Mol Cell. Cardiol. 32(6): 973-984, 2000.

#Bailey, B.A., K. Dipla, S. Li, and S.R. Houser.
Cellular basis of contractile derangements of hypertrophied feline ventricular myocytes.
J. Mol. Cell. Cardiol. 29: 1823-1835, 1997.

#Rokosh, D.G., A.F.R. Stewart, K.C. Chang, B.A. Bailey, J.S. Karliner, S.A. Camacho,
C.S. Long, and P.C. Simpson. 
Alpha 1-adrenergic receptor subtype mRNAs are differentially regulated by Alpha 1-adrenergic and other hypertrophic stimuli in cardiac myocytes in culture and in vivo-Repression of  Alpha 1B and
Alpha 1D but induction of Alpha 1C.
J. Biol. Chem. 271(10): 5839-5843, 1996.

#Stewart, A.F.R., D.G. Rokosh, B.A. Bailey, L.R. Karns, K.C. Chang, C.S. Long,
K. Kariya, and P.C. Simpson. 
Cloning of the rat a1C-Adrenergic receptor from cardiac myocytes: a1C, a1B, and a1D mRNAs are present in cardiac myocytes, but not in cardiac fibroblasts.
Circ. Res. 75: 796-802, 1994.  

#Rokosh, D.G., B.A. Bailey, A.F.R. Stewart, L.R. Karns, C.S. Long, P.C. Simpson. 
Distribution of a1C-Adrenergic receptor mRNA in adult rat tissues by RNase protection
assay and comparison with a1B and a1D. 
Biochem. Biophys. Res. Commun. 200(3): 1177-1184, 1994.

#Pollack, P.S., B.A. Bailey, R. Budjak, E. Fernandez, and S.R. Houser. 
Progressive feline pressure-overload: Noninvasive assessment correlates with abnormalities in single cells. 
Am. J. Physiol. 264: H1307-H1314, 1993.

#Bailey, B.A. and S.R. Houser. 
Sarcoplasmic reticulum-related changes in cytosolic calcium in pressure-overload-induced feline LV hypertrophy.  Am. J. Physiol. 265: H2009-H2016, 1993.

#Bailey, B.A. and S.R. Houser. 
Calcium transients in feline left ventricular myocytes with hypertrophy induced by slow
progressive pressure overload. 
J. Mol. Cell. Cardiol. 24: 365-373, 1992.

S.R. Houser, K. Dipla, V. Piacentino, III., B. Bailey.
Ionic Homeostasis in Left Ventricular Hypertrophy
In: Left Ventricular Hypertrophy.
Editor: Prof. D. Sheridan. Churchill Communications Europe LTD. 1999.

*Wilson, R., *Welsh, K., R. *Whelan, Bailey, B.A.
Protection from Ischemia/Reperfusion Injury in the Isolated Mouse Heart. 
FASEB J. 15 (5): A769, 2001.

*Welsh, K., *Wilson, R., Bailey, B.A.
Are there gender-based differences in murine cardiac function?
FASEB J. 15 (5): A1139, 2001.

#*Brychta, R.J., *R. Whelan, *R. Wilson, *K. Welsh, *R. Pape, B. A. Bailey.
Chronic aerobic training of adult mice induces cardiac hypertrophy with maintenance of normal contractility but does not protect from ischemia/reperfusion injury. 
Circulation 102(18): II-76, 2000.

#*Petre, R. E. ,*Thompson, D, and Bailey, B.A.
“Development of a Technique for Isolation of Viable, Individual Myocytes from the Mouse Heart.
Journal of PA. Academy of Science. 73:174, 2000.

#*Valiant, C., *Wirth, E., *Whelan, R., *Adenaike, M.,  *Welsh, K., and Bailey, B.A.
Ischemic Preconditioning in the Mouse Heart Improves Postischemic Function.
Journal of PA Academy of Science.73:182, 2000.

*Whelan, R.S. and B.A. Bailey. 
Ischemic Preconditioning enhances postischemic function in isolate mouse hearts. 
FASEB J. 13 (5): A762, 1999.

#* Brychta, R.J., *R.S. Whelan, and B.A. Bailey. 
The response of the Murine heart to chronic, aerobic exercise. 
J. PA Acad. of Science. 72: 153, 1999.

#* Wagman, L.M., *N.R. McElhaney and B.A. Bailey. 
The effects of altered taurine levels in ischemia/reperfusion injury in the rat heart. 
J. PA Acad. of Science. 72: 185, 1999.

#Bailey, BA, Y. Yang, C. Hefner, K. Marjulies, S. Houser.
The abundance of L-type Ca channel a1c subunit isoforms is different in normal human and
rat ventricular myocytes.
J. Mol. Cell. Cardiol. 30:A128, 1998.

#Toaldo, G-L., B.A. Bailey, C. Hefner, and S.R. Houser.
a-adrenergic stimulation causes coordinate inverse effects on SERCa2 and Na/Ca exchanger mRNA.
CIRC II 92(8): I-503, 1995.

#Dipla, K., C. Hefner, B.A. Bailey, and S.R. Houser.
An antisense Na/Ca exchanger oligonucleotide slows the decay of the systolic calcium transient in
neonatal rat ventricular myocytes.
CIRC II 92(8): I-373, 1995.

Bailey, B.A., J.A. Mattiello, C.A. Hefner, and S.R. Houser.
Expression of L-Type Ca2+ channel isoforms in neonatal rat ventricular myocytes with
phenylephrine induced hypertrophy.
Biophys. J. 68 (2 Pt. 2): A260, 1995.

Toaldo, G-L., C.A. Hefner, B.A. Bailey, and S.R. Houser.
Reduced SERCA expression correlates with prolongation of the systolic Ca2+ transient in
hypertrophied neonatal rat ventricular myocytes.
Biophys. J. 68(2 Pt. 2): A311, 1995.

#Bailey, B.A., C. Hefner, G-L. Toaldo, K. Dipla, and S.R. Houser.
Calcium efflux via Na/Ca exchange is increased in hypertrophied rat ventricular myocytes.
CIRC. II 92(8): I-235, 1995.

#Bailey, B.A., J.P. Gaughan, and S.R. Houser.
Different L-type calcium channel isoforms are present in neonatal and adult cardiac myocytes.
CIRC II 92(8): I-372, 1995.

Myofilament Calcium Sensitivity is Greater in Male than in Female Ventricular Myocytes.  Oral Presentation at the American Heart Association Scientific Sessions held in Chicago, IL Nov. 2006.  Co-authors on abstract are UC students Monica Crary (Class of '07), John Dillon (Class of '06) and Jennifer Nolan (Class of '04). 

Sex-based differences in the contractile properties of freshly isolated murine cardiac myocytes.  Poster presented at Mid-Atlantic Pharmacology Society (MAPS) Meeting held at the Wistar Institute of the University of Pennsylvania, Oct. 2005.  Co-authored and presented with Monica Crary (Class of '07).

Are there differences in intracellular calcium handling between male and female murine cardiac myocytes? Poster presented at Mid-Atlantic Pharmacology Society (MAPS) Meeting held at the Wistar Institute of the University of Pennsylvania, Oct. 2005.  Co-authored and presented with John Dillon (Class of '06).

Are There Sex-based Differences in Whole-heart Response to Sympathetic Nervous System Agonists? Poster presented at Mid-Atlantic Pharmacology Society (MAPS) Meeting held at Wyeth Pharmaceuticals, Oct. 2004.  Co-authored with Michelle Segalov (Class of '05) and Samit Patel (Class of '05). Presented by Michelle Segalov.

Are There Sex-Based Differences in Cardiac Muscle Cell Response to Adrenergic Stimulation? Poster presented at Mid-Atlantic Pharmacology Society (MAPS) Meeting held at Wyeth Pharmaceuticals, Oct. 2004.  Co-authored with and presented by Jacqueline Slakoper (Class of '05).

Sex-based differences in the response of cardiac myocytes to elevated calcium and pacing frequency.  Poster presented at Sigma Xi Student Research Day held at Thomas Jefferson School of Medicine, March 2004.  Presented with Jennifer Nolan (Class of '04). 

Sex-based Differences in Myocardial Calcium Responsiveness.  Poster presented at Sigma Xi Student Research Day held at Thomas Jefferson School of Medicine, March 2004.  Presented with Amanda DiNofia (Class of '04)

Ischemia/Reperfusion Injury in the Isolated Mouse Heart. Experimental Biology. Orlando, FL April, 2001.

Are there gender-based differences in murine cardiac function? Experimental Biology. Orlando, FL April, 2001.

Chronic aerobic training of adult mice induces cardiac hypertrophy with maintenance of normal contractility but does not protect from ischemia/reperfusion injury.
American Heart Association Scientific Sessions. New Orleans, LA November, 2000.

Ischemic Preconditioning enhances postischemic function in isolated mouse hearts. 
Experimental Biology. Washington, DC April, 1999.

Cardiac Research: A Journey of the Heart. Presented to the Young Scholars Program at College Misercordia, July 1999.

The abundance of L-type Ca channel a1c subunit isoforms is different in normal human and
rat ventricular myocytes. 
Moderated Poster Session.
International Society for Heart Research, XVI Word Congress, Rhodes, Greece. May, 1998.